Vitamin D And Ocd
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Vitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorder
Highlights
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OCD is a frequent disorder in children and adolescents that has a poorly understood a etiopathogenesis.
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One carbon metabolism that includes vitamin B12, folic acid and homocysteine can play a role in the aetiopathogenesis of OCD.
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Vitamin D can play a role in the aetiopathogenesis of many psychiatric disorders.
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Findings of this study demonstrated lower levels of vitamin B12 and higher levels of homocysteine in OCD patients.
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Vitamin D levels were found to be lower in OCD patients and had a negative correlation with disease severity.
Abstract
Obsessive compulsive disorder (OCD) is a complex disorder with a poorly understood aetiopathogenesis. One carbon metabolism that includes vitamin B12, folic acid and homocysteine has been investigated in many psychiatric disorders like OCD. In recent years, vitamin D has also been considered to contribute to many of these psychiatric disorders. In this study we investigated whether vitamin B12, homocysteine and vitamin D play a role in the aetiology of paediatric OCD. With this aim we compared 52 children and adolescent OCD patients with 30 healthy controls. The participants were tested for vitamin B12, folic acid, homocysteine and vitamin D levels and were evaluated with a sociodemographic form, state-trait anxiety inventory 1 and 2, Kovacs Depression Inventory and Yale-Brown Obsessive Compulsive Scale (Y-BOCS). As a result we found significantly lower levels of vitamin B12 and vitamin D and higher levels of homocysteine in the patient group compared to control group (p values for all three scores were <0.001), whereas there was no significant difference between groups in terms of folate levels (p=0.083). This demonstrates that one carbon metabolism and vitamin D deficiency can play a role in the aetiology of OCD.
Keywords
Obsessive compulsive disorder
Vitamin B12
Folate
Homocysteine
Vitamin D
Aetiopathogenesis
© 2017 Elsevier B.V. All rights reserved.
Source: https://www.sciencedirect.com/science/article/abs/pii/S016517811631441X#:~:text=Vitamin%20D%20can%20play%20a,aetiopathogenesis%20of%20many%20psychiatric%20disorders.&text=Findings%20of%20this%20study%20demonstrated,of%20homocysteine%20in%20OCD%20patients.&text=Vitamin%20D%20levels%20were%20found,negative%20correlation%20with%20disease%20severity.
